7r1j

Structural highlights

Function

NORV_ECOLI Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the reductase at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase.^{[1] [2]}

References

1. ↑ Gardner AM, Helmick RA, Gardner PR. Flavorubredoxin, an inducible catalyst for nitric oxide reduction and detoxification in Escherichia coli. J Biol Chem. 2002 Mar 8;277(10):8172-7. Epub 2001 Dec 18. PMID:11751865 doi:http://dx.doi.org/10.1074/jbc.M110471200
2. ↑ Gomes CM, Giuffre A, Forte E, Vicente JB, Saraiva LM, Brunori M, Teixeira M. A novel type of nitric-oxide reductase. Escherichia coli flavorubredoxin. J Biol Chem. 2002 Jul 12;277(28):25273-6. Epub 2002 May 6. PMID:12101220 doi:http://dx.doi.org/10.1074/jbc.M203886200