8hdf

Structural highlights

Function

FAA23_MYCTU Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension (Probable). Involved in the biosynthesis of sulfolipid 1 (SL-1) (PubMed:17389997, PubMed:17768256).^{[1] [2] [3]}

References

1. ↑ Gokhale RS, Saxena P, Chopra T, Mohanty D. Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids. Nat Prod Rep. 2007 Apr;24(2):267-77. PMID:17389997 doi:10.1039/b616817p
2. ↑ Lynett J, Stokes RW. Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages. Microbiology (Reading). 2007 Sep;153(Pt 9):3133-3140. PMID:17768256 doi:10.1099/mic.0.2007/007864-0
3. ↑ Lynett J, Stokes RW. Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages. Microbiology (Reading). 2007 Sep;153(Pt 9):3133-3140. PMID:17768256 doi:10.1099/mic.0.2007/007864-0