Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics. See also [1].
Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA. In contrast, netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove. , locally displacing the water molecules of the spine of hydration.
