Introduction

Function

Bile Salt Uptake

HBV/HDV Infection

Structure

Proline/Glycine Hinge

Core and Panel Domains

Sodium Binding Region

Significant Residues

The vast majority of residues involved in bile salt uptake are also involved in HBV/HDV infection. of Human NTCP have been shown to be vital for preS1 domain recognition along with bile salt uptake. Residues 157-165 (INSERT GREEN LINK) have also been shown to be vital for preS1 recognition and bile salt uptake. Altering residues in either of these two sections hinders preS1 binding and therefore HBV/HDV infection. However, these mutations also prevent bile salt uptake.

Mechanisms

Bile Salt Uptake

HBV/HDV Infection

HBV/HDV infection is reliant on multiple properties that must be present on both the virus itself and the NTCP protein. First, the HBV/HDV capsid must be myristolated (INSERT BLUE LINK) in order for proper recognition by NTCP. Residues 2-48 are the most significant residues of HBV/HDV that are highly conserved amongst these viruses that are vital for infection. Specifically, residues 8-17 on HBV/HDV have been identified as the most important. These residues are NPLGFFPDHQ.

Medical Relevance