Active and Inactive Form
The TSHR protein exists in two states, active and inactive. The sticks out from the cell membrane into the space outside the cell. The contains 7 alpha helices that reside within the cell membrane. The exists when bound to the thyroid stimulating hormone (TSH)
Figure 1: Inactive form of the thyrotropin receptor shown in blue. Active form of the thyrotropin receptor shown in green. Extracellular domain rotates about the dynamic hinge region. Transmembrane domain also sees some movement.
