Structural highlights
Function
PLVAP_MOUSE Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.[1]
References
- ↑ Herrnberger L, Seitz R, Kuespert S, Bösl MR, Fuchshofer R, Tamm ER. Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice. Histochem Cell Biol. 2012 Nov;138(5):709-24. PMID:22782339 doi:10.1007/s00418-012-0987-3
