Introduction

Structure

cartoon depiction of NTCP topology

Sodium Taurocholate Co-Transporting Polypeptide, or NTCP, is one continuous polypeptide chain consisting of a total of 9 transmembrane α helices (TM1-9). There are two distinct domains within the quaternary structure of NTCP: a (blue) and a (red), both being a part of the same polypeptide chain. The core domain includes 6 transmembrane &alpha helices (TM2-4 and TM7-9) while the panel domain consists of 3 transmembrane &alpha helices (TM1 and TM5-6).

Conformational Change

Bile Salt Transport

Medical Relevancy

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.