Introduction

Sodium Taurocholate Co-Transporting Polypeptide, or NTCP, is a transporter protein that is found in

Structure

cartoon depiction of NTCP topology

Sodium Taurocholate Co-Transporting Polypeptide, or NTCP, is one continuous polypeptide chain consisting of a total of 9 transmembrane α helices (TM1-9). There are two distinct domains within the quaternary structure of NTCP: a (blue) and a (red), both being a part of the same polypeptide chain. The core domain includes 6 transmembrane α helices (TM2-4 and TM7-9) and demonstrates two-fold pseudosymmetry while the panel domain consists of 3 transmembrane α helices (TM1 and TM5-6) and does not display symmetry. Within the core domain, there is a unique crossover between TM-3 and TM-8 that is known as the . This motif is important because this is where the transporter's substrate binding site is located.

Conformational Change

Bile Salt Transport

Medical Relevancy

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