1ji7

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spinqualitylabelsall models 1ji7, resolution 1.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal Structure of TEL SAM Polymer

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

TEL is a transcriptional repressor that is a frequent target of, chromosomal translocations in a large number of hematalogical, malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional, regulatory proteins. The self-associating property of TEL-SAM is essential, for cell transformation in many, if not all of these diseases. Here we, show that the TEL-SAM domain forms a helical, head-to-tail polymeric, structure held together by strong intermolecular contacts, providing the, first clear demonstration that SAM domains can polymerize. Our results, also suggest a mechanism by which SAM domains could mediate the spreading, of transcriptional repression complexes along the chromosome.

Disease

Known diseases associated with this structure: Leukemia, acute myeloid, somatic OMIM:[600618]

About this Structure

1JI7 is a Single protein structure of sequence from Homo sapiens with SO4 as ligand. Full crystallographic information is available from OCA.

Reference

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression., Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU, EMBO J. 2001 Aug 1;20(15):4173-82. PMID:11483520

Page seeded by OCA on Mon Nov 12 17:40:56 2007