Structural highlights
Function
RS2_THET8 Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.[HAMAP-Rule:MF_00291_B]
Publication Abstract from PubMed
The ribosome is the target of a large number of antibiotics. Here, we report a 3.4-A-resolution crystal structure of bactobolin A bound to 70S ribosome-tRNA complex. The antibiotic binds at a previously unseen site in the 50S subunit and displaces tRNA bound at the P-site. It thus likely has a similar mechanism of action as blasticidin S despite binding to a different site. The structure also rationalizes previously identified resistance mutations.
Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics.,Amunts A, Fiedorczuk K, Truong TT, Chandler J, Peter Greenberg E, Ramakrishnan V J Mol Biol. 2015 Jan 3. pii: S0022-2836(14)00654-8. doi:, 10.1016/j.jmb.2014.12.018. PMID:25562208[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Amunts A, Fiedorczuk K, Truong TT, Chandler J, Peter Greenberg E, Ramakrishnan V. Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics. J Mol Biol. 2015 Jan 3. pii: S0022-2836(14)00654-8. doi:, 10.1016/j.jmb.2014.12.018. PMID:25562208 doi:http://dx.doi.org/10.1016/j.jmb.2014.12.018
