1k2p
From Proteopedia
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Crystal structure of Bruton's tyrosine kinase domain
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Overview
Bruton's tyrosine kinase is intimately involved in signal transduction, pathways regulating survival, activation, proliferation, and, differentiation of B lineage lymphoid cells. Mutations in the human btk, gene are the cause of X-linked agammaglobulinemia, a male immune, deficiency disorder characterized by a lack of mature, immunoglobulin-producing B lymphocytes. We have determined the x-ray, crystal structure of the Bruton's tyrosine kinase kinase domain in its, unphosphorylated state to a 2.1 A resolution. A comparison with the, structures of other tyrosine kinases and a possible mechanism of, activation unique to Bruton's tyrosine kinase are provided.
Disease
Known diseases associated with this structure: Agammaglobulinemia, type 1, X-linked OMIM:[300300], XLA and isolated growth hormone deficiency OMIM:[300300]
About this Structure
1K2P is a Single protein structure of sequence from Homo sapiens. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
Reference
Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia., Mao C, Zhou M, Uckun FM, J Biol Chem. 2001 Nov 2;276(44):41435-43. Epub 2001 Aug 29. PMID:11527964
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