1k78
From Proteopedia
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Pax5(1-149)+Ets-1(331-440)+DNA
Contents |
Overview
Pax5 regulates the B cell-specific expression of the mb-1 gene together, with members of the Ets family of transcriptional activators. The Ets, proteins on their own bind poorly to the Pax5/Ets binding site, but can be, recruited to the site by cooperative interactions with Pax5. The structure, of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA, reveals the molecular details of the selective recruitment of different, Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to, both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1, contacts with DNA. The ability of one protein to alter the DNA, sequence-specific contacts of another provides a general mechanism for, combinatorial regulation of transcription.
Disease
Known disease associated with this structure: Lymphoplasmacytoid lymphoma OMIM:[167414]
About this Structure
1K78 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502
Page seeded by OCA on Mon Nov 12 17:48:04 2007
