5lbj

Structural highlights

Function

LDRD_ECOLI Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing and nucleoid condensation of the host cell (PubMed:12123448). Overexpression induces stress-response and a number of membrane protein genes. May inhibit ATP synthesis due to its insertion in the cell inner membrane (By similarity).[UniProtKB:P0DPD0]^{[1] [2]}

References

1. ↑ Kawano M, Oshima T, Kasai H, Mori H. Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli. Mol Microbiol. 2002 Jul;45(2):333-49. PMID:12123448 doi:10.1046/j.1365-2958.2002.03042.x
2. ↑ Fozo EM, Kawano M, Fontaine F, Kaya Y, Mendieta KS, Jones KL, Ocampo A, Rudd KE, Storz G. Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. Mol Microbiol. 2008 Dec;70(5):1076-93. PMID:18710431 doi:10.1111/j.1365-2958.2008.06394.x