8h68

Structural highlights

Function

MALE_ECO57 Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).NMAD1_CAEEL Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:25936839). N(6)-methyladenosine (m6A) DNA is involved in epigenetic transgenerational inheritance (PubMed:25936839). Plays an essential role in DNA replication and repair in the germline during meiosis (PubMed:31283754). Binds to components of the DNA replication machinery such as top-2, and directs their localization to DNA to control DNA replication (PubMed:31283754).^{[1] [2]}

References

1. ↑ Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, Aravind L, He C, Shi Y. DNA Methylation on N6-Adenine in C. elegans. Cell. 2015 May 7;161(4):868-78. PMID:25936839 doi:10.1016/j.cell.2015.04.005
2. ↑ Wang SY, Mao H, Shibuya H, Uzawa S, O'Brown ZK, Wesenberg S, Shin N, Saito TT, Gao J, Meyer BJ, Colaiácovo MP, Greer EL. The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline. PLoS Genet. 2019 Jul 8;15(7):e1008252. PMID:31283754 doi:10.1371/journal.pgen.1008252