Structural highlights
Function
PDE6D_HUMAN Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
Publication Abstract from PubMed
This study shows that the prenylated C-terminus of RPGR can bind to PDE6delta with high affinity, suggesting two distinct binding sites of the RPGR/PDE6delta complex. The serine residue at the -3 position relative to the prenylated cysteine seems to play a key role in defining the selectivity of PDE6delta towards ciliary prenylated cargo. [Image: see text]
The N- and C-terminal ends of RPGR can bind to PDE6delta.,Fansa EK, O'Reilly NJ, Ismail S, Wittinghofer A EMBO Rep. 2015 Dec;16(12):1583-5. doi: 10.15252/embr.201541404. Epub 2015 Nov 9. PMID:26553937[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Fansa EK, O'Reilly NJ, Ismail S, Wittinghofer A. The N EMBO Rep. 2015 Dec;16(12):1583-5. PMID:26553937 doi:10.15252/embr.201541404
