1ln6
From Proteopedia
STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)
Overview
The structural changes that accompany activation of a G-protein coupled receptor (GPCR) are not well understood. To better understand the activation of rhodopsin, the GPCR responsible for visual transduction, we report studies on the three-dimensional structure for the activated state of this receptor, metarhodopsin II. Differences between the three-dimensional structure of ground state rhodopsin and metarhodopsin II, particularly in the cytoplasmic face of the receptor, suggest how the receptor is activated to couple with transducin. In particular, activation opens a groove on the surface of the receptor that could bind the N-terminal helix of the G protein, transducin alpha.
About this Structure
1LN6 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin., Choi G, Landin J, Galan JF, Birge RR, Albert AD, Yeagle PL, Biochemistry. 2002 Jun 11;41(23):7318-24. PMID:12044163 Page seeded by OCA on Sat May 3 00:05:05 2008
