1mif

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spinqualitylabelsall models 1mif, resolution 2.6Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Macrophage migration inhibitory factor (MIF) was the first cytokine to be, described, but for 30 years its role in the immune response remained, enigmatic. In recent studies, MIF has been found to be a novel pituitary, hormone and the first protein identified to be released from immune cells, on glucocorticoid stimulation. Once secreted, MIF counterregulates the, immunosuppressive effects of steroids and thus acts as a critical, component of the immune system to control both local and systemic immune, responses. We report herein the x-ray crystal structure of human MIF to, 2.6 angstrom resolution. The protein is a trimer of identical subunits., Each monomer contains two antiparallel alpha-helices that pack against a, four-stranded beta-sheet. The monomer has an additional two beta-strands, that interact with the beta-sheets of adjacent subunits to form the, interface between monomers. The three beta-sheets are arranged to form a, barrel containing a solvent-accessible channel that runs through the, center of the protein along a molecular 3-fold axis. Electrostatic, potential maps reveal that the channel has a positive potential, suggesting that it binds negatively charged molecules. The elucidated, structure for MIF is unique among cytokines or hormonal mediators, and, suggests that this counterregulator of glucocorticoid action participates, in novel ligand-receptor interactions.

Disease

Known diseases associated with this structure: Persistent Mullerian duct syndrome, type I OMIM:[600957], Rheumatoid arthritis, systemic juvenile, susceptibility to OMIM:[153620]

About this Structure

1MIF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor., Sun HW, Bernhagen J, Bucala R, Lolis E, Proc Natl Acad Sci U S A. 1996 May 28;93(11):5191-6. PMID:8643551

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