5izd

Structural highlights

Function

GADH_THEAC NADP-dependent dehydrogenase of the nED (non-phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D-glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3-phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes.^{[1] [2]}

References

1. ↑ Reher M, Schonheit P. Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily. FEBS Lett. 2006 Feb 20;580(5):1198-204. Epub 2006 Jan 19. PMID:16458304 doi:http://dx.doi.org/10.1016/j.febslet.2006.01.029
2. ↑ Jung JH, Lee SB. Identification and characterization of Thermoplasma acidophilum glyceraldehyde dehydrogenase: a new class of NADP+-specific aldehyde dehydrogenase. Biochem J. 2006 Jul 1;397(1):131-8. PMID:16566751 doi:http://dx.doi.org/10.1042/BJ20051763