Structural highlights
Function
METAA_THEMA Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Has weak activity with succinyl-CoA as the acyl donor.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Goudarzi M, Born TL. Purification and characterization of Thermotoga maritima homoserine transsuccinylase indicates it is a transacetylase. Extremophiles. 2006 Oct;10(5):469-78. doi: 10.1007/s00792-006-0522-3. Epub 2006 , May 18. PMID:16708165 doi:http://dx.doi.org/10.1007/s00792-006-0522-3
