Structural highlights
Function
SUGA_MYCTU Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for the translocation of the substrate across the membrane.[1]
References
- ↑ Kalscheuer R, Weinrick B, Veeraraghavan U, Besra GS, Jacobs WR Jr. Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21761-6. doi:, 10.1073/pnas.1014642108. Epub 2010 Nov 30. PMID:21118978 doi:http://dx.doi.org/10.1073/pnas.1014642108
