1n1l
From Proteopedia
CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)
Overview
[reaction: see text] In this, the second of two letters, we describe the elaboration of the pyrrolidine-5,5-trans-lactam template to delineate the requirements for optimal substitution of the pyrrolidine and lactam nitrogen atoms. Central to the strategy is the use of rapid iterative synthesis in conjunction with X-ray crystal structure determination of ligand-protein complexes.
About this Structure
1N1L is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray crystal structure data in the optimization of P3 and P4 substituents., Andrews DM, Chaignot H, Coomber BA, Good AC, Hind SL, Johnson MR, Jones PS, Mills G, Robinson JE, Skarzynski T, Slater MJ, Somers DO, Org Lett. 2002 Dec 12;4(25):4479-82. PMID:12465917 Page seeded by OCA on Sat May 3 01:58:38 2008
Categories: Hepatitis c virus | Protein complex | Andrews, D M. | Chaignot, H. | Coomber, B A. | Good, A C. | Hind, S L. | Jones, P S. | Mill, G. | Robinson, J E. | Skarzynski, T. | Slater, M J. | Somers, D O.N. | Cofactor peptide | Helicase | Inhibitor | Nonstructural protein | Serine protease | Viral protein
