4xtu

Structural highlights

Function

BIRA_MYCTU Catalyzes the transfer of biotin onto a conserved lysine residue of the biotin carboxyl carrier protein (BCCP) domain of acetyl-CoA carboxylase and converts it to active holo-BCCP (PubMed:18509457, PubMed:24723382). Forms an acyl-adenylate intermediate (PubMed:18509457, PubMed:24723382). Cannot use GTP or desthiobiotin (PubMed:18509457).^{[1] [2]}

See Also

• Biotin Protein Ligase 3D structures

References

1. ↑ Purushothaman S, Gupta G, Srivastava R, Ramu VG, Surolia A. Ligand specificity of group I biotin protein ligase of Mycobacterium tuberculosis. PLoS One. 2008 May 28;3(5):e2320. doi: 10.1371/journal.pone.0002320. PMID:18509457 doi:http://dx.doi.org/10.1371/journal.pone.0002320
2. ↑ Ma Q, Akhter Y, Wilmanns M, Ehebauer MT. Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis. Protein Sci. 2014 Apr 9. doi: 10.1002/pro.2475. PMID:24723382 doi:http://dx.doi.org/10.1002/pro.2475