1nko

From Proteopedia

Energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7

Overview

The high-resolution crystal structure of the functional N-terminal domain, from the extracellular region of the human natural killer cell inhibitory, receptor p75/AIRM1 or Siglec-7 has been determined at 1.45 A resolution;, it was obtained from a crystal belonging to a primitive monoclinic space, group, with unit-cell parameters a = 32.65, b = 49.72, c = 39.79 A, alpha, = gamma = 90, beta = 113 degrees. The structure reported here belongs to a, different space group than the previously described Siglec-7 structure and, was obtained using a bacterial expression system. The structure unveils, the fine structural requirements adopted by a natural killer cell, inhibitory receptor of the Siglec family in target-cell recognition and, binding.

About this Structure

1NKO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1., Dimasi N, Moretta A, Moretta L, Biassoni R, Mariuzza RA, Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):401-3. Epub 2004, Jan 23. PMID:14747738

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