| Structural highlights
Function
UT2_HUMAN Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism.[1] [2] Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.[3] [4]
References
- ↑ Bagnasco SM, Peng T, Janech MG, Karakashian A, Sands JM. Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. Am J Physiol Renal Physiol. 2001 Sep;281(3):F400-6. PMID:11502588 doi:10.1152/ajprenal.2001.281.3.F400
- ↑ Mistry AC, Mallick R, Fröhlich O, Klein JD, Rehm A, Chen G, Sands JM. The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein. J Biol Chem. 2007 Oct 12;282(41):30097-106. PMID:17702749 doi:10.1074/jbc.M705866200
- ↑ Olivès B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, Cartron JP, Bailly P. Molecular characterization of a new urea transporter in the human kidney. FEBS Lett. 1996 May 20;386(2-3):156-60. PMID:8647271 doi:10.1016/0014-5793(96)00425-5
- ↑ Martial S, Olivès B, Abrami L, Couriaud C, Bailly P, You G, Hediger MA, Cartron JP, Ripoche P, Rousselet G. Functional differentiation of the human red blood cell and kidney urea transporters. Am J Physiol. 1996 Dec;271(6 Pt 2):F1264-8. PMID:8997401 doi:10.1152/ajprenal.1996.271.6.F1264
|
