6bv8

Structural highlights

Function

PRRP1_ARATH Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Preferentially cleaves at the unusual cleavage site, but also able to cleave at the classical cleavage site. Also involved in the maturation of mRNAs in mitochondria.^{[1] [2] [3]}

References

1. ↑ Gobert A, Gutmann B, Taschner A, Gossringer M, Holzmann J, Hartmann RK, Rossmanith W, Giege P. A single Arabidopsis organellar protein has RNase P activity. Nat Struct Mol Biol. 2010 Jun;17(6):740-4. doi: 10.1038/nsmb.1812. Epub 2010 May , 16. PMID:20473316 doi:http://dx.doi.org/10.1038/nsmb.1812
2. ↑ Placido A, Sieber F, Gobert A, Gallerani R, Giege P, Marechal-Drouard L. Plant mitochondria use two pathways for the biogenesis of tRNAHis. Nucleic Acids Res. 2010 Nov;38(21):7711-7. doi: 10.1093/nar/gkq646. Epub 2010 Jul, 25. PMID:20660484 doi:http://dx.doi.org/10.1093/nar/gkq646
3. ↑ Gutmann B, Gobert A, Giege P. PRORP proteins support RNase P activity in both organelles and the nucleus in Arabidopsis. Genes Dev. 2012 May 15;26(10):1022-7. doi: 10.1101/gad.189514.112. Epub 2012 May , 1. PMID:22549728 doi:http://dx.doi.org/10.1101/gad.189514.112