6de9
From Proteopedia
mitoNEET bound to furosemide
Structural highlights
FunctionCISD1_HUMAN Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions.[1] [2] Publication Abstract from PubMedMitoNEET (gene cisd1) is a mitochondrial outer membrane [2Fe-2S] protein and is a potential drug target in several metabolic diseases. Previous studies have demonstrated that mitoNEET functions as a redox-active and pH-sensing protein that regulates mitochondrial metabolism, although the structural basis of the potential drug binding site(s) remains elusive. Here we report the crystal structure of the soluble domain of human mitoNEET with a sulfonamide ligand, furosemide. Exploration of the high-resolution crystal structure is used to design mitoNEET binding molecules in a pilot study of molecular probes for use in future development of mitochondrial targeted therapies for a wide variety of metabolic diseases, including obesity, diabetes and neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand.,Geldenhuys WJ, Long TE, Saralkar P, Iwasaki T, Nunez RAA, Nair RR, Konkle ME, Menze MA, Pinti MV, Hollander JM, Hazlehurst LA, Robart AR Commun Chem. 2019;2. doi: 10.1038/s42004-019-0172-x. Epub 2019 Jul 3. PMID:32382661[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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