1w53

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spinqualitylabelsall models 1w53, resolution 1.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

KINASE RECRUITMENT DOMAIN OF THE STRESS PHOSPHATASE RSBU

Overview

RsbU is a positive regulator of the activity of sigmaB, the general, stress-response sigma factor of Gram+ microorganisms. The N-terminal, domain of this protein has no significant sequence homology with proteins, of known function, whereas the C-terminal domain is similar to the, catalytic domains of PP2C-type phosphatases. The phosphatase activity of, RsbU is stimulated greatly during the response to stress by associating, with a kinase, RsbT. This association leads to the induction of sigmaB, activity. Here we present data on the activation process and demonstrate, in vivo that truncations in the N-terminal region of RsbU are deleterious, for the activation of RsbU. This conclusion is supported by comparisons of, the phosphatase activities of full-length and a truncated form of RsbU ... [(full description)]

About this Structure

1W53 is a [Single protein] structure of sequence from [Bacillus subtilis] with XE and GOL as [ligands]. Full crystallographic information is available from [OCA].

Reference

Functional and structural characterization of RsbU, a stress signaling protein phosphatase 2C., Delumeau O, Dutta S, Brigulla M, Kuhnke G, Hardwick SW, Volker U, Yudkin MD, Lewis RJ, J Biol Chem. 2004 Sep 24;279(39):40927-37. Epub 2004 Jul 19. PMID:15263010

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