6m8o

Structural highlights

Function

LYTR_STAA8 Member of the two-component regulatory system LytR/LytS that regulates genes involved in autolysis, programmed cell death, biofilm formation and cell wall metabolism (PubMed:19502411). Participates also in sensing and responding to host defense cationic antimicrobial peptides (HDPs) (PubMed:23733465). Upon phosphorylation by LytS, functions as a transcription regulator by direct binding to promoter regions of target genes including lrgA and lrgB, to positively regulate their expression (PubMed:8824633, PubMed:25491472).^{[1] [2] [3] [4]}

See Also

• Response regulator 3D structure

References

1. ↑ Sharma-Kuinkel BK, Mann EE, Ahn JS, Kuechenmeister LJ, Dunman PM, Bayles KW. The Staphylococcus aureus LytSR two-component regulatory system affects biofilm formation. J Bacteriol. 2009 Aug;191(15):4767-75. PMID:19502411 doi:10.1128/JB.00348-09
2. ↑ Yang SJ, Xiong YQ, Yeaman MR, Bayles KW, Abdelhady W, Bayer AS. Role of the LytSR two-component regulatory system in adaptation to cationic antimicrobial peptides in Staphylococcus aureus. Antimicrob Agents Chemother. 2013 Aug;57(8):3875-82. PMID:23733465 doi:10.1128/AAC.00412-13
3. ↑ Lehman MK, Bose JL, Sharma-Kuinkel BK, Moormeier DE, Endres JL, Sadykov MR, Biswas I, Bayles KW. Identification of the amino acids essential for LytSR-mediated signal transduction in Staphylococcus aureus and their roles in biofilm-specific gene expression. Mol Microbiol. 2015 Feb;95(4):723-37. PMID:25491472 doi:10.1111/mmi.12902
4. ↑ Brunskill EW, Bayles KW. Identification of LytSR-regulated genes from Staphylococcus aureus. J Bacteriol. 1996 Oct;178(19):5810-2. PMID:8824633 doi:10.1128/jb.178.19.5810-5812.1996