1w5u
From Proteopedia
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GRAMICIDIN D FROM BACILLUS BREVIS (ETHANOL SOLVATE)
Overview
Gramicidin D (gD) is a naturally occurring ionophoric antibiotic that, forms membrane channels specific for monovalent cations. The crystal, structure of the RbCl complex of gD has been determined at 1.14 A, resolution from low-temperature (100 K) synchrotron-radiation data with a, final R of 16%. The structure was refined with anisotropic temperature, factors for all non-H atoms and with partial occupancies for many of them., The asymmetric unit in the crystal contains four crystallographically, independent molecules that form two right-handed antiparallel, double-stranded dimers. There are seven distinct rubidium-binding sites in, each dimeric channel. The occupancy factors of Rb cations are between 0.11, and 0.35 and the total ion contents of the two crystallographically, independent ... [(full description)]
About this Structure
1W5U is a [Single protein] structure of sequence from [Brevibacillus brevis] with RB, CL, FOR and EOH as [ligands]. Full crystallographic information is available from [OCA].
Reference
Structure of gramicidin D-RbCl complex at atomic resolution from low-temperature synchrotron data: interactions of double-stranded gramicidin channel contents and cations with channel wall., Glowka ML, Olczak A, Bojarska J, Szczesio M, Duax WL, Burkhart BM, Pangborn WA, Langs DA, Wawrzak Z, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):433-41. Epub 2005, Mar 24. PMID:15805598
Page seeded by OCA on Mon Oct 29 18:22:32 2007
Categories: Brevibacillus brevis | Single protein | Bojarska, J. | Burkhart, B.M. | Duax, W.L. | Glowka, M.L. | Langs, D.A. | Olczak, A. | Pangborn, W.A. | Szczesio, M. | Wawrzak, Z. | CL | EOH | FOR | RB | Gramicidin double-stranded channel | Gramicidin rbcl complex | High resolution data | Peptide antibiotic
