6xcl

Publication Abstract from PubMed

Guanine quadruplex recognition has gained increasing attention, inspired by the growing awareness of the key roles played by these non-canonical nucleic acid architectures in cellular regulatory processes. We report here the solution and solid-state studies of a novel planar platinum(II) complex that is easily assembled from a simple ligand, and exhibits notable binding affinity for guanine quadruplex structures, while maintaining good selectivity for guanine quadruplex over duplex structures. A crystal structure of this ligand complexed with a telomeric quadruplex confirms double end-capping, with dimerization at the 5' interface.

Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.,Miron CE, van Staalduinen L, Rangaswamy AMM, Chen M, Liang Y, Jia Z, Mergny JL, Petitjean A Angew Chem Int Ed Engl. 2020 Oct 22. doi: 10.1002/anie.202012520. PMID:33090592^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.