7rj3

Structural highlights

Function

GARA_MYCTU Involved in regulation of glutamate metabolism. Acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB.^{[1] [2] [3]}

References

1. ↑ O'Hare HM, Duran R, Cervenansky C, Bellinzoni M, Wehenkel AM, Pritsch O, Obal G, Baumgartner J, Vialaret J, Johnsson K, Alzari PM. Regulation of glutamate metabolism by protein kinases in mycobacteria. Mol Microbiol. 2008 Dec;70(6):1408-23. doi: 10.1111/j.1365-2958.2008.06489.x., Epub 2008 Oct 17. PMID:19019160 doi:http://dx.doi.org/10.1111/j.1365-2958.2008.06489.x
2. ↑ England P, Wehenkel A, Martins S, Hoos S, Andre-Leroux G, Villarino A, Alzari PM. The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling. FEBS Lett. 2009 Jan 22;583(2):301-7. doi: 10.1016/j.febslet.2008.12.036. Epub, 2008 Dec 27. PMID:19114043 doi:http://dx.doi.org/10.1016/j.febslet.2008.12.036
3. ↑ Nott TJ, Kelly G, Stach L, Li J, Westcott S, Patel D, Hunt DM, Howell S, Buxton RS, O'Hare HM, Smerdon SJ. An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis. Sci Signal. 2009 Mar 24;2(63):ra12. PMID:19318624 doi:2/63/ra12