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Structural highlights

Function

FHBP_NEIMH A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH) (PubMed:16785547). Binding contributes to the avoidance of complement-mediated lysis by N.meningitidis (Probable).^{[1] [2]}

References

1. ↑ Madico G, Welsch JA, Lewis LA, McNaughton A, Perlman DH, Costello CE, Ngampasutadol J, Vogel U, Granoff DM, Ram S. The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance. J Immunol. 2006 Jul 1;177(1):501-10. PMID:16785547
2. ↑ Madico G, Welsch JA, Lewis LA, McNaughton A, Perlman DH, Costello CE, Ngampasutadol J, Vogel U, Granoff DM, Ram S. The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance. J Immunol. 2006 Jul 1;177(1):501-10. PMID:16785547