7uqc

Structural highlights

Disease

HECAM_HUMAN Macrocephaly-intellectual disability-autism syndrome;Megalencephalic leukoencephalopathy with subcortical cysts. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.

Function

HECAM_HUMAN Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation.^{[1] [2]}

References

1. ↑ Chung Moh M, Hoon Lee L, Shen S. Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma. J Hepatol. 2005 Jun;42(6):833-41. PMID:15885354 doi:10.1016/j.jhep.2005.01.025
2. ↑ Moh MC, Zhang C, Luo C, Lee LH, Shen S. Structural and functional analyses of a novel ig-like cell adhesion molecule, hepaCAM, in the human breast carcinoma MCF7 cells. J Biol Chem. 2005 Jul 22;280(29):27366-74. PMID:15917256 doi:10.1074/jbc.M500852200