1tco
From Proteopedia
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TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)
Overview
The X-ray structure of the ternary complex of a calcineurin A fragment, calcineurin B, FKBP12, and the immunosuppressant drug FK506 (also known as, tacrolimus) has been determined at 2.5 A resolution, providing a, description of how FK506 functions at the atomic level. In the structure, the FKBP12-FK506 binary complex does not contact the phosphatase active, site on calcineurin A that is more than 10 A removed. Instead, FKBP12-FK506 is so positioned that it can inhibit the dephosphorylation of, its macromolecular substrates by physically hindering their approach to, the active site. The ternary complex described here represents the, three-dimensional structure of a Ser/Thr protein phosphatase and provides, a structural basis for understanding calcineurin inhibition by, FKBP12-FK506.
About this Structure
1TCO is a [Protein complex] structure of sequences from [Bos taurus] with CA, ZN, FE, PO4, MYR and FK5 as [ligands]. Active as [[1]], with EC number [3.1.3.16]. Full crystallographic information is available from [OCA].
Reference
X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex., Griffith JP, Kim JL, Kim EE, Sintchak MD, Thomson JA, Fitzgibbon MJ, Fleming MA, Caron PR, Hsiao K, Navia MA, Cell. 1995 Aug 11;82(3):507-22. PMID:7543369
Page seeded by OCA on Mon Oct 29 18:23:14 2007
Categories: Bos taurus | Protein complex | Caron, P.R. | Fitzgibbon, M.J. | Fleming, M.A. | Griffith, J.P. | Hsiao, K. | Kim, E.E. | Kim, J.L. | Navia, M.A. | Sintchak, M.D. | Thomson, J.A. | CA | FE | FK5 | MYR | PO4 | ZN | Complex (hydrolase/isomerase) | Immunosuppressant
