Structural highlights
Function
BLAC_BACLI
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The title compound 4 has been prepared in four steps from ethylglycinate in 63% overall yield. This amino analog of citric acid has been co-crystallized with the class A beta-lactamase BS3 of Bacillus licheniformis and the structure of the complex fully analyzed by X-ray diffraction. Tris-ethyl aminocitrate 3 and the free tris-acid 4 have been tested against a member beta-lactamase from all distinct subgroups. They are novel inhibitors of class A beta-lactamases, still modest but more potent than citrate and isocitrate.
2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A beta-lactamase BS3 of Bacillus licheniformis.,Beck J, Sauvage E, Charlier P, Marchand-Brynaert J Bioorg Med Chem Lett. 2008 Jul 1;18(13):3764-8. Epub 2008 May 16. PMID:18515103[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Beck J, Sauvage E, Charlier P, Marchand-Brynaert J. 2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A beta-lactamase BS3 of Bacillus licheniformis. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3764-8. Epub 2008 May 16. PMID:18515103 doi:10.1016/j.bmcl.2008.05.045
