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3emo

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Revision as of 15:22, 1 November 2023 by OCA (Talk | contribs)

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Crystal structure of transmembrane Hia 973-1098

Structural highlights

3emo is a 3 chain structure with sequence from Haemophilus influenzae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q48152_HAEIF

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The Hia autotransporter of Haemophilus influenzae belongs to the trimeric autotransporter subfamily and mediates bacterial adherence to the respiratory epithelium. In this report, we show that the structure of Hia is characterized by a modular architecture containing repeats of structurally distinct domains. Comparison of the structures of HiaBD1 and HiaBD2 adhesive repeats and a nonadhesive repeat (a novel fold) shed light on the structural determinants of Hia adhesive function. Examination of the structure of an extended version of the Hia translocator domain revealed the structural transition between the C-terminal translocator domain and the N-terminal passenger domain, highlighting a highly intertwined domain that is ubiquitous among trimeric autotransporters. Overall, this study provides important insights into the mechanism of Hia adhesive activity and the overall structure of trimeric autotransporters.

Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter.,Meng G, St Geme JW 3rd, Waksman G J Mol Biol. 2008 Dec 26;384(4):824-36. Epub 2008 Oct 11. PMID:18948113^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Meng G, St Geme JW 3rd, Waksman G. Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter. J Mol Biol. 2008 Dec 26;384(4):824-36. Epub 2008 Oct 11. PMID:18948113 doi:10.1016/j.jmb.2008.09.085