3t5t

Structural highlights

Function

VLDE_STRHL Involved in the biosynthesis of the antifungal agent validamycin A (PubMed:16725283). Catalyzes the condensation between GDP-valienol and validamine 7-phosphate via a nonglycosidic C-N bond formation to yield validoxylamine A 7'-phosphate (PubMed:21766819).^{[1] [2]}

References

1. ↑ Singh D, Seo MJ, Kwon HJ, Rajkarnikar A, Kim KR, Kim SO, Suh JW. Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704). Gene. 2006 Jul 5;376(1):13-23. doi: 10.1016/j.gene.2005.12.035. Epub 2006 Apr 5. PMID:16725283 doi:http://dx.doi.org/10.1016/j.gene.2005.12.035
2. ↑ Asamizu S, Yang J, Almabruk KH, Mahmud T. Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis. J Am Chem Soc. 2011 Aug 10;133(31):12124-35. doi: 10.1021/ja203574u. Epub 2011, Jul 18. PMID:21766819 doi:http://dx.doi.org/10.1021/ja203574u