1p8v
From Proteopedia
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CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A
Contents |
Overview
Direct interaction between platelet receptor glycoprotein Ibalpha, (GpIbalpha) and thrombin is required for platelet aggregation and, activation at sites of vascular injury. Abnormal GpIbalpha-thrombin, binding is associated with many pathological conditions,including, occlusive arterial thrombosis and bleeding disorders. The crystal, structure of the GpIbalpha-thrombin complex at 2.6 angstrom resolution, reveals simultaneous interactions of GpIbalpha with exosite I of one, thrombin molecule,and with exosite II of a second thrombin molecule. In, the crystal lattice,the periodic arrangement of GpIbalpha-thrombin, complexes mirrors a scaffold that could serve as a driving force for tight, platelet adhesion. The details of these interactions reconcile, GpIbalpha-thrombin binding modes that are presently, controversial,highlighting two distinct interfaces that are potential, targets for development of novel antithrombotic drugs.
Disease
Known diseases associated with this structure: Bernard-Soulier syndrome, type A OMIM:[606672], Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930], Nonarteritic anterior ischemic optic neuropathy, susceptibility to OMIM:[606672], von Willebrand disease, platelet-type OMIM:[606672]
About this Structure
1P8V is a Protein complex structure of sequences from Homo sapiens with NAG, MES and DFP as ligands. Active as Thrombin, with EC number 3.4.21.5 Full crystallographic information is available from OCA.
Reference
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation., Dumas JJ, Kumar R, Seehra J, Somers WS, Mosyak L, Science. 2003 Jul 11;301(5630):222-6. PMID:12855811
Page seeded by OCA on Mon Nov 12 18:41:01 2007
