Structural highlights
4abj is a 2 chain structure with sequence from Bos taurus and Helianthus annuus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.45Å |
| Ligands: | , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
TRY1_BOVIN
Publication Abstract from PubMed
Flower power: Potent protease inhibitors containing triazolyl mimics of cis and trans backbone amides were engineered based on the structure of the sunflower trypsin inhibitor 1. The biologically relevant cis-Pro motif was successfully replaced with a non-prolyl unit. High-resolution crystal structures of 1,4- and 1,5-disubstituted 1,2,3-triazolyl peptidomimetics can serve in the design of tailor-made Bowman-Birk inhibitors.
Braces for the Peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations.,Tischler M, Nasu D, Empting M, Schmelz S, Heinz DW, Rottmann P, Kolmar H, Buntkowsky G, Tietze D, Avrutina O Angew Chem Int Ed Engl. 2012 Apr 10;51(15):3708-12. doi: 10.1002/anie.201108983. , Epub 2012 Feb 28. PMID:22374650[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Tischler M, Nasu D, Empting M, Schmelz S, Heinz DW, Rottmann P, Kolmar H, Buntkowsky G, Tietze D, Avrutina O. Braces for the Peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations. Angew Chem Int Ed Engl. 2012 Apr 10;51(15):3708-12. doi: 10.1002/anie.201108983. , Epub 2012 Feb 28. PMID:22374650 doi:10.1002/anie.201108983
