From Proteopedia

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3D structures of Serine hydroxymethyltransferase

Updated on 15-November-2023 {{#tree:id=OrganizedByTopic|openlevels=0|

• SHMT

• • 6dk3 – hSHMT 2 – human
    
  • 5x3v – hSHMT 2 (mutant)
    
  • 7pzz – AtSHMT 2 – Arabidopsis thaliana
    
  • 7q00 – AtSHMT 4
    
  • 7qpe – AtSHMT 6
    
  • 7qx8 – AtSHMT 7
    
  • 3gbx – SHMT – Salmonella typhimurium
    
  • 3n0l – SHMT – Campylobacter jejuni
    
  • 3pgy – SHMT + glycine – Staphylococcus aureus
    
  • 4mso – BcSHMT – Burkholderia cenocepacia
    
  • 3ecd – SHMT – Burkholderia pseudomallei
    
  • 4bhd – MjSHMT – Methanocaldococcus jannaschii
    
  • 4p3m – SHMT – Psychromonas ingrahamii
    
  • 4wxb – StSHMT – Streptococcus thermophilus
    
  • 6ti3 – StSHMT (mutant) + threonine
    
  • 5vc2, 6f93 – SHMT – Helicobacter pylori
    
  • 5vmb – SHMT – Acinetobacter baumannii
    
  • 5z0y – SHMT – Pichia pastoris
    
  • 7qcw – SHMT – Pseudomonas chlororaphis <br /

• SHMT + PLP

• • 1bj4 - hSHMT 1 + PLP
    
  • 6fl5 – hSHMT 1 (mutant) + PLP
    
  • 4pvf, 8aql, 8qi7, 8ssj – hSHMT 2 + PLP derivative
    
  • 1cj0, 1rv4, 1rvu – rSHMT 1 (mutant) + PLP – rabbit
    
  • 1eji – SHMT + PLP derivative – mouse
    
  • 6uxh, 6uxi, 6uxk , 6uxl– sbSHMT 8 + PLP derivative – soybean
    
  • 6cd0, 6cd1 – bmSHMT 3 + PLP derivatives - barrel medic
    
  • 2dkj – TtSHMT + PLP – Thermus thermophilus
    
  • [[8suj] – TtSHMT + PLP derivative
    
  • 1kkj – GsSHMT + PLP – Geobacillus stearothermophilus
    
  • 1yjz, 2vgs, 2vi8, 2vmn, 2vmp, 2vmr, 2vmv, 2w7d, 2w7f, 2w7i – GsSHMT (mutant) + PLP
    
  • 3g8m – EcSHMT (mutant) + PLP – Eschericha coli
    
  • 4j5u – SHMT + PLP derivative – Rickettsia rickettsia
    
  • 4n0w - BcSHMT + PLP
    
  • 4uqv - MjSHMT + PLP
    
  • 4o6z – SHMT (mutant) + PLP – Plasmodium falciparum
    
  • 3h7f – MtSHMT + PLP derivative – Mycobacteria tuberculosis
    
  • 6ymd, 6yme, 6ymf – MtSHMT + PLP derivative – Aphanothece halophytica
    
  • 6ti1, 6ti4 – StSHMT (mutant) + PLP derivative
    
  • 7e13 - SHMT + PLP – Erigeron canadensis
    
  • 4pff – PvSHMT + PLP – Plasmodium vivax
    
  • 7ujh, 7uji, 8dom – GmSHMT (mutant) + PLP derivative – Glycine max
    

• SHMT binary complex + PLP

• • 8a11 - hSHMT + RNA + PLP derivative – Cryo EM
    
  • 1rv3, 1rvy - rSHMT 1 (mutant) + glycine + PLP
    
  • 1ls3 - rSHMT 1 + formyl hydrofolate derivative + PLP derivative
    
  • 6uxj - sbSHMT 8 + formyl hydrofolate derivative + PLP
    
  • 6ccz – bmSHMT 3 + selenourea + PLP derivative
    
  • 1dfo – EcSHMT + formyl hydrofolate + PLP derivative
    
  • 1kkp – GsSHMT + serine + PLP
    
  • 1yjy, 2vgu, 2via, 2vmt, 2vmw, 2w7k – GsSHMT (mutant) + serine + PLP
    
  • 2vmx, 2w7g, 2w7l – GsSHMT (mutant) + threonine + PLP
    
  • 1kl1 – GsSHMT + glycine + PLP
    
  • 1yjs, 2vgt, 2vgv, 2vgw, 2vi9, 2vib, 2vmo, 2vmq, 2vms, 2vmu, 2vmz, 2w7e, 2w7h, 2w7j, 2w7m – GsSHMT (mutant) + glycine + PLP
    
  • 4ot8 - BcSHMT + serine + PLP
    
  • 4otl - BcSHMT + glycine + PLP
    
  • 4tn4, 5gvk, 5gvl, 5gvm, 5gvn, 5gvp, 5yfy, 5yg0, 5yg1, 5yfz, 5yg2, 5yg3, 5yg4, 5xms, 5xmt, 5xmu, 5xmv – PvSHMT + inhibitor + PLP derivative – Plasmodium vivax
    
  • 5xmp, 5xmq, 5xmr – PvSHMT (mutant) + inhibitor + PLP derivative
    
  • 4wxf – StSHMT + glycine + PLP derivative
    
  • 6yrw – StSHMT (mutant) + Ser + PLP
    
  • 4wxg – StSHMT + allo-threonine + glycine
    

• SHMT ternary complex + PLP

• • 6h3c – hSHMT 2 in Brisc and Brca1-A complex – Cryo EM
    
  • 6r8f – hSHMT 2 (mutant) in Brisc and Brca1-A complex – Cryo EM
    
  • 6qvg, 6qvl – hSHMT 2 + PLP + antifolate drug
    
  • 8fjt, 8fju – hSHMT 2 + PLP + Gly + inhibitor
    
  • 8fsd – sbSHMT + THF derivative + PLP + Gly
    
  • 5v7i – hSHMT 2 + inhibitor + glycine + PLP
    
  • 6smn – AtSHMT 2 + PLP + antifolate drug
    
  • 6smw – AtSHMT 2 + PLP derivative + antifolate drug
    
  • 6smr – AtSHMT 4 + PLP derivative + antifolate drug
    
  • 1kl2 – GsSHMT + formyl hydrofolate + glycine + PLP
    
  • 2vmy – GsSHMT (mutant) + formyl hydrofolate + glycine + PLP
    
  • 1eqb - EcSHMT (mutant) + formyl hydrofolate + glycine + PLP
    
  • 6tgh – StSHMT (mutant) + Ser + PLP derivative + pyridine derivative
    
  • 6uld – MtSHMT + Ser + Gly + PLP
    
  • 4tn4, 5gvk, 5gvl, 5gvm, 5gvn, 5gvp, 5xms, 5xmt, 5xmu, 5xmv, 5yfy, 5yg0, 5yg1, 5yg4 – PvSHMT + inhibitor + PLP derivative
    
  • 5xmp, 5xmq, 5xmr – PvSHMT (mutant) + inhibitor + PLP derivative
    
  • 7x5o – EfSHMT + THF derivative + PLP derivative – Enterococcus faecium
    
  • 7v3d – EfSHMT + PLP + inhibitor
    
  • 7x5n – EfSHMT + PLP derivative + inhibitor
    
  • 8ssy – TtSHMT + PLP derivative + Ser
    
  • 8dsk – GmSHMT + THF derivative + Gly + PLP derivative
    

• SHMT other complexes

• • 7byi – hSHMT 2 + carbenoxolone
    
  • 6h3c – hSHMT 2 in BRISC complex – Cryo EM
    
  • 4oyt – PvSHMT + Gly + folinic acid
    

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