7tcy

Structural highlights

Function

TNK1_HUMAN Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.^{[1] [2]}

References

1. ↑ Felschow DM, Civin CI, Hoehn GT. Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. Biochem Biophys Res Commun. 2000 Jun 24;273(1):294-301. PMID:10873601 doi:http://dx.doi.org/10.1006/bbrc.2000.2887
2. ↑ Hoare S, Hoare K, Reinhard MK, Lee YJ, Oh SP, May WS Jr. Tnk1/Kos1 knockout mice develop spontaneous tumors. Cancer Res. 2008 Nov 1;68(21):8723-32. doi: 10.1158/0008-5472.CAN-08-1467. PMID:18974114 doi:http://dx.doi.org/10.1158/0008-5472.CAN-08-1467