Structural highlights
Disease
ZDHC9_HUMAN Lujan-Fryns syndrome. The disease is caused by variants affecting the gene represented in this entry.
Function
ZDHC9_HUMAN Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (Probable). The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (PubMed:16000296). May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942).[1] [2] (Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell.[3]
References
- ↑ Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes RJ, Linder ME. DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity J Biol Chem. 2005 Sep 2;280(35):31141-8. PMID:16000296 doi:10.1074/jbc.M504113200
- ↑ Adachi N, Hess DT, McLaughlin P, Stamler JS. S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary. J Biol Chem. 2016 Sep 16;291(38):20232-46. PMID:27481942 doi:10.1074/jbc.M116.725762
- ↑ Mesquita FS, Abrami L, Sergeeva O, Turelli P, Qing E, Kunz B, Raclot C, Paz Montoya J, Abriata LA, Gallagher T, Dal Peraro M, Trono D, D'Angelo G, van der Goot FG. S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity. Dev Cell. 2021 Oct 25;56(20):2790-2807.e8. PMID:34599882 doi:10.1016/j.devcel.2021.09.016
