6kjc

Structural highlights

Function

PCEST_PENRW Esterase that can hydrolyze the side chain of lovastatin to produce monacolin J (PubMed:28619444, PubMed:31839596). Is also able to hydrolyze the side chains of mevastatin and pravastatin, but not simvastatin (PubMed:28619444).^{[1] [2]}

References

1. ↑ Huang X, Liang Y, Yang Y, Lu X. Single-step production of the simvastatin precursor monacolin J by engineering of an industrial strain of Aspergillus terreus. Metab Eng. 2017 Jul;42:109-114. PMID:28619444 doi:10.1016/j.ymben.2017.06.005
2. ↑ Liang Y, Lu X. Structural insights into the catalytic mechanism of lovastatin hydrolase. J Biol Chem. 2020 Jan 24;295(4):1047-1055. PMID:31839596 doi:10.1074/jbc.RA119.011936