Structural highlights
Function
MEGL_FUSNN Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia, and that of L-homocysteine (By similarity). Can also use L-cysteine as substrate, catalyzing its alpha,beta-elimination; this activity seems to only minimally contribute to the production of hydrogen sulfide (H2S) by F.nucleatum in the oral cavity, which is toxic for a large variety of cells in periodontal regions (PubMed:21798982).[UniProtKB:Q8L0X4][1]
See Also
References
- ↑ Suwabe K, Yoshida Y, Nagano K, Yoshimura F. Identification of an L-methionine γ-lyase involved in the production of hydrogen sulfide from L-cysteine in Fusobacterium nucleatum subsp. nucleatum ATCC 25586. Microbiology (Reading). 2011 Oct;157(Pt 10):2992-3000. PMID:21798982 doi:10.1099/mic.0.051813-0
