7da9

Structural highlights

Function

HSPB_PSEP6 Involved in the nicotine degradation. Catalyzes the cleavage of 6-hydroxy-3-succinoylpyridine (HSP) by incorporation of oxygen at the 3-position to produce to 2,5-dihydroxypyridine (DHP) and succinic semialdehyde.^[1]

References

1. ↑ Tang H, Yao Y, Zhang D, Meng X, Wang L, Yu H, Ma L, Xu P. A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida. J Biol Chem. 2011 Nov 11;286(45):39179-87. PMID:21949128 doi:10.1074/jbc.M111.283929