Structural highlights
Publication Abstract from PubMed
A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.
A novel minimal motif for left-handed G-quadruplex formation.,Das P, Winnerdy FR, Maity A, Mechulam Y, Phan AT Chem Commun (Camb). 2021 Mar 9;57(20):2527-2530. doi: 10.1039/d0cc08146a. PMID:33690751[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Das P, Winnerdy FR, Maity A, Mechulam Y, Phan AT. A novel minimal motif for left-handed G-quadruplex formation. Chem Commun (Camb). 2021 Mar 9;57(20):2527-2530. PMID:33690751 doi:10.1039/d0cc08146a
