8hmg

Structural highlights

Function

RGLG2_ARATH E3 ubiquitin-protein ligase that mediates the formation of 'Lys-63'-linked ubiquitin chains. Regulates apical dominance by acting on the auxin transport proteins abundance (PubMed:17586653). Mediates ubiquitination and subsequent proteasomal degradation of ERF053 in response to drought stress. Acts as a negative regulator of drought stress response (PubMed:22095047).^{[1] [2]}

References

1. ↑ Yin XJ, Volk S, Ljung K, Mehlmer N, Dolezal K, Ditengou F, Hanano S, Davis SJ, Schmelzer E, Sandberg G, Teige M, Palme K, Pickart C, Bachmair A. Ubiquitin lysine 63 chain forming ligases regulate apical dominance in Arabidopsis. Plant Cell. 2007 Jun;19(6):1898-911. PMID:17586653 doi:10.1105/tpc.107.052035
2. ↑ Cheng MC, Hsieh EJ, Chen JH, Chen HY, Lin TP. Arabidopsis RGLG2, functioning as a RING E3 ligase, interacts with AtERF53 and negatively regulates the plant drought stress response. Plant Physiol. 2012 Jan;158(1):363-75. PMID:22095047 doi:10.1104/pp.111.189738