5o8n

Publication Abstract from PubMed

This paper describes the design, development and successful use of an on-chip goniometer for room-temperature macromolecular crystallography via acoustically induced rotations. We present for the first time a low cost, rate-tunable, acoustic actuator for gradual in-fluid sample reorientation about varying axes and its utilisation for protein structure determination on a synchrotron beamline. The device enables the efficient collection of diffraction data via a rotation method from a sample within a surface confined droplet. This method facilitates efficient macromolecular structural data acquisition in fluid environments for dynamical studies.

An acoustic on-chip goniometer for room temperature macromolecular crystallography.,Burton CG, Axford D, Edwards AMJ, Gildea RJ, Morris RH, Newton MI, Orville AM, Prince M, Topham PD, Docker PT Lab Chip. 2017 Nov 10. doi: 10.1039/c7lc00812k. PMID:29124258^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.