2vkq

Structural highlights

Disease

5NT3A_HUMAN Hemolytic anemia due to pyrimidine 5' nucleotidase deficiency. The disease is caused by variants affecting the gene represented in this entry.

Function

5NT3A_HUMAN Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458).^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Amici A, Ciccioli K, Naponelli V, Raffaelli N, Magni G. Evidence for essential catalytic determinants for human erythrocyte pyrimidine 5'-nucleotidase. Cell Mol Life Sci. 2005 Jul;62(14):1613-20. PMID:15968458 doi:10.1007/s00018-005-5135-y
2. ↑ Monecke T, Buschmann J, Neumann P, Wahle E, Ficner R. Crystal Structures of the Novel Cytosolic 5'-Nucleotidase IIIB Explain Its Preference for m7GMP. PLoS One. 2014 Mar 6;9(3):e90915. doi: 10.1371/journal.pone.0090915. eCollection , 2014. PMID:24603684 doi:http://dx.doi.org/10.1371/journal.pone.0090915