1qgr
From Proteopedia
|
STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA (II CRYSTAL FORM, GROWN AT LOW PH)
Overview
Cytosolic proteins bearing a classical nuclear localization signal enter, the nucleus bound to a heterodimer of importin-alpha and importin-beta, (also called karyopherin-alpha and -beta). The formation of this, heterodimer involves the importin-beta-binding (IBB) domain of, importin-alpha, a highly basic amino-terminal region of roughly 40, amino-acid residues. Here we report the crystal structure of human, importin-beta bound to the IBB domain of importin-alpha, determined at 2.5, A and 2.3 A resolution in two crystal forms. Importin-beta consists of 19, tandemly repeated HEAT motifs and wraps intimately around the IBB domain., The association involves two separate regions of importin-beta, recognizing structurally distinct parts of the IBB domain: an, amino-terminal extended moiety and a carboxy-terminal helix. The structure, indicates that significant conformational changes occur when importin-beta, binds or releases the IBB domain domain and suggests how dissociation of, the importin-alpha/beta heterodimer may be achieved upon nuclear entry.
About this Structure
1QGR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of importin-beta bound to the IBB domain of importin-alpha., Cingolani G, Petosa C, Weis K, Muller CW, Nature. 1999 May 20;399(6733):221-9. PMID:10353244
Page seeded by OCA on Mon Nov 12 18:53:03 2007
